Histological study of the effects of cypermethrin on liver and kidney tissues of mice model

Cypermethrin is a synthetic pyrethroid pesticide widely used to protect crop against pest and insect, resulting human health and their related environment are under great risk due to undesirable toxicity. The present study was carried out to evaluate extinct of damage caused by subcutaneous introduction of cypermethrin on liver and kidney tissue of mice model. Forty switch albino mice were dispense mainly into two groups as control and treatment group. The animals of three treatment groups (each group contain ten animal) were provided ordinary poultry food containing cypermethrin at dose level of 5, 7.5 & 10 ml/kg body weight respectively for different period based on the number of treated group. After ending treatment period, the animals were sacrificed for histological study and visualized under light microscope. Result were demonstrated enlargement in the sinusoidal space, vacuole formations in hepatocytes, leucocytic infiltrations, congestion of blood vessels with hemorrhage in hepatic tissue and shrinkage of glomeruli, necrosis of renal tubules, deleted blood vassal and severe congestion of renal glomerulus along with hemorrhage in renal tissues compared with the regular organization of their control. Therefore, we strongly recommend for the ban of cypermethrin and searching out nontoxic pesticide for agricultural use. Keyword: Cypermethrin, histology, kidney, liver and Mus musculus.